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Andersen NB, Malmlf K, Johansen PB, et al

There is a consensus that GPX and GCL are the two enzymes in the glutathione pathway that are upregulated by estradiol

47 Taken together, these data suggest the reduced GSH/GSSG antioxidant capacity is insufficient to counter excessive OH production, and that unopposed OH can reach the nucleus to create the oxidative DNA adduct, 8-oxo-dG

Our work demonstrates that the response to exogenous glucose in the brain is also impaired in GLP-1R KO mice

For more information on optimizing your hypothyroidism care, read the Paloma article Why Do I Still Have Hypothyroid Symptoms With Normal Labs? Make sure you are taking your thyroid medication consistently and regularly

doi:10.1186/s12903-025-06454-9 Gillespie KM, White MJ, Kemps E, Moore H, Dymond A, Bartlett SE